Reactive Mesothelial Cells In Pleural Fluid Cytology

Reactive mesothelial cells reactive mesothelial cells in pleural fluid reactive mesothelial cells are found when there is infection or inflammation present in a body cavity.

Reactive mesothelial cells in pleural fluid cytology.

The distinction between reactive and malignant mesothelial cells has long been a challenge in effusion cytology. Papanicolaou x100 breast adenocarcinoma cells in pleural effusion. Because of the difficulty in distinguishing reactive mh from mm even in tissue specimens such as small pleural biopsies several studies have used immunohistochemical markers to distinguish between reactive and neoplastic mesothelial cells 3 8 or between adenocarcinoma reactive mh and mm in serous effusions. Neoplastic transformation of mesothelial cells results in malignant mesothelioma an aggressive tumor especially the pleura.

Mesothelial cells form conspicuous layer of regularly spaced bland cuboidal cells along pleural surface. Atypical mesothelial cell proliferation. Mesothelial cytopathology is a large part of cytopathology. Numerous mesothelial cells are seen in this pleural fluid from a dog with a transudative effusion with concurrent diapedesis of red blood cells or hemorrhage.

Hyperplastic mesothelial cells with slightly enlarged nuclei micronucleoli and a clear space or window between adjacent cells present singly and in small clusters. An introduction to cytopathology is in the cytopathology article. Common cells present in pleural fluid include neutrophils lymphocytes monocytes mesothelial cells and red blood. The many faces of reactive mesothelial cells.

Epithelial or lining cells most commonly mesothelial cells 1 the appearance and presentation of nucleated cells found in pleural fluid and whether they are considered common benign or abnormal is discussed below. Larger clusters of hyperplastic mesothelial cells showing mildly nuclear atypia with small nucleoli. 9 14 these studies suggest that 2. Bap1 a new marker that is helpful in distinguishing reactive mesothelial cells from malignant mesothelioma.

Reactive pleural effusion showing acute and chronic cells normal mesothelial cells and alveolar macrophages in aggregates and dispersed cells with rounded nuclei and vacuolated cytoplasm. The article deals with cytopathology specimens from spaces lined with mesothelium i e. It deals with pericardial fluid peritoneal fluid and pleural fluid.